Restriction modification systems as engines of diversity
نویسندگان
چکیده
منابع مشابه
Restriction modification systems as engines of diversity
Restriction modification (RM) systems provide protection against a broad spectrum of phages. However, the likelihood of a phage permanently bypassing this can be as high as 0.1 per infection (Korona et al., 1993) which makes for a relatively weak defense. Here we argue that, apart from providing such transient defenses, RM systems can facilitate long-term coexistence of many bacterial strains. ...
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A restriction (R) endonuclease recognizes a specific DNA sequence and introduces a double-strand break (Fig. 1A). A cognate modification (M) enzyme methylates the same sequence and thereby protects it from cleavage. Together, these two enzymes form a restriction-modification system. The genes encoding the restriction endonuclease and the cognate modification enzyme are often tightly linked and ...
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ژورنال
عنوان ژورنال: Frontiers in Microbiology
سال: 2015
ISSN: 1664-302X
DOI: 10.3389/fmicb.2015.00528